Social theories and humanitarian movements, despite their good intentions, have had limited effectiveness. This paper introduces Socio-Systemic science as a conceptual and implementation framework designed for effective high impact systemic action. The science of Socio-Systemic impact is led by the Social Architect who understands how to consciously catalyse key drivers of systemic change. The rise of a systems-based worldview forms the basis of a new way of understanding modern problems, inferring the kind of thinking and leadership required today. The Social Architect is a new entity in this development, working to apply grounded sociological science and understandings of natural systems to improving the human condition. Where traditional activism falls short through structural illiteracy and continually stumbles in engaging mere symptoms of world issues, the Social Architects act as the compassionate analysts addressing the systemic causes of world issues. We can no longer turn a blind eye to structural violence and systemic failure. Inside the dark heart of structural violence are the keys of societal re-architecting that are in fact our only hope out of it. The first part of this paper outlines the science of Socio-Systemic impact. The second part explains how to put the science into practice; reviews current implementation methods being deployed by leading Social Architects; outlines the key skills and roles of the Social Architect working individually as well as strategies for integral systemic action, and, lastly, suggests further action strategies and prospects for the future.